It is of clinical importance to screen gestational diabetes mellius for improvement of maternal morbidity and perinatal mortality caused by diabetes mellitus.
In this study, we performed glucose challenge test(GCT), followed by 100g-oral glucose tolerance test(OGTT) in case that the result of 50g-GCT showed serum glucose level higher than 130 mg/dl.
Purpose of this study was to evaluate the accuracy of GCT for screening of gestational diabetes mellitus.
The author performed the GCT in pregnant women from gestational 24 weeks to gestational 28 weeks who had antenatal care and delivered at Department of OB & GY of Ewha Womans University Hospital from December, 1990 to January, 1994.
@ES The results were as follows:
@EN 1. When the GCT cut off level was higher than 130mg/dl, the population was 28.5%, and among them 16.4% was diagnosed gestational diabetes mellitus.
2. There was statistically significant correlation between GCT level(above 130 mg/dl) and age, gravidity, HbA1, and cesarean section rate(p<0.05). Positive correlation between GCT levels and HbA1 were also observed (p<0.01).
3. The risk factors were present in 77.6% and 22.4% in the population showing GCT level higher than 130mg/dl., and below 130mg/dl. Respectively.
4. When the cut off point of GCT level was 130mg/dl, sensitivity, specificity and accuracy for gestational diabetes mellitus were 100%, 74.4%, 75.4% and when the cut off point was 140mg/dl, sensitivity, specificity and accuracy were 89.5%,
86.3%,
86.4%.
5. When the GCT level and HbA1 level (8.0%) were combined, the author could raise the specificity with 100% of sensitivity.
The results of the study indicate that measurement of 50g-GCT, considering age, gravidity and HbA1 would contribute to the diagnostic accuracy of gestational diabetes mellitus, and the convenience and cost-effectiveness of patients.
In conclusion, the measurement of 50g-GCT is very helpful to the screening of gestational diabetes mellitus.
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